INTRACELLULAR OSTEOPONTIN PROTECTS FROM AUTOIMMUNITY-DRIVEN LYMPHOMA DEVELOPMENT INHIBITING TLR9-MYD88-STAT3 SIGNALING

Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling

Abstract Background Autoimmune disorders, including Systemic Lupus Erythematosus (SLE), are associated with increased incidence of hematological malignancies.The matricellular protein osteopontin (OPN) has been linked to SLE pathogenesis, as SLE patients show increased serum levels of OPN and often polymorphisms in its gene.Although widely studied

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Austerity Policies, Public Expenditure, and Development from a Gender Perspective: What Is the Status of Mexican and Brazilian Women?

This article examines the impact of austerity policies Clamps on gender inequality in Mexico and Brazil.More specifically, it seeks to discuss the need to reconcile public expenditure with a development strategy that actually includes a gender perspective.The feminization of poverty is of particular interest, as it is the basis upon which we try to

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Sleep and Obesity

Rising global prevalence and incidence of obesity lead to increased cardiovascular-renal complications and cancers.Epidemiological studies reported a worldwide trend towards suboptimal sleep duration and poor sleep quality in parallel with this obesity epidemic.From rodents and human models, it is highly plausible that abnormalities in sleep, both

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